Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.310 AlteredExpression disease BEFREE Moreover, as activation of δ-opioid receptor by a non-peptidic δ-opioid receptor agonist also modulates the expression, maturation and processing of amyloid precursor protein and β-secretase activity, the potential role of these effects on ischemic stroke caused dementia or Alzheimer's disease are also discussed. 31535637 2020
Entrez Id: 100048912
Gene Symbol: CDKN2B-AS1
CDKN2B-AS1
0.180 GeneticVariation disease BEFREE There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS. 31757599 2020
Entrez Id: 463
Gene Symbol: ZFHX3
ZFHX3
0.130 GeneticVariation disease BEFREE There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS. 31757599 2020
Entrez Id: 7099
Gene Symbol: TLR4
TLR4
0.100 AlteredExpression disease BEFREE Finally, we showed that Vsig4 could interact with TLR4 and repress its expression, subsequently alleviating ischemic stroke. 31784084 2020
Entrez Id: 4018
Gene Symbol: LPA
LPA
0.100 Biomarker disease BEFREE Alirocumab significantly reduced other lipid/lipoproteins (including lipoprotein[a]) similarly in patients with/without MI/ischemic stroke. 31076261 2020
Entrez Id: 5327
Gene Symbol: PLAT
PLAT
0.100 Biomarker disease BEFREE Who will benefit more from low-dose alteplase in acute ischemic stroke? 31226920 2020
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
0.100 Biomarker disease BEFREE The Effect of Clot Volume and Permeability on Response to Intravenous Tissue Plasminogen Activator in Acute Ischemic Stroke. 31810719 2020
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
0.100 Biomarker disease BEFREE The only way of managing patients with ischemic stroke is the use of intravenous tissue plasminogen activator and endovascular thrombectomy. 31612315 2020
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
0.100 Biomarker disease BEFREE Intravenous recombinant tissue plasminogen activator is considered for acute ischemic stroke. 31623507 2020
Entrez Id: 105375847
Gene Symbol: CERNA3
CERNA3
0.100 Biomarker disease BEFREE Two blinded reviewers evaluated patients' eligibility for endovascular thrombectomy using published collateral imaging (multiphase CTA) criteria compared with CTP using the selection criteria of the Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention with Trevo (DAWN) and Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE-3) trials. 31806593 2020
Entrez Id: 185
Gene Symbol: AGTR1
AGTR1
0.100 GeneticVariation disease BEFREE There is increasing evidence suggesting that dysregulation of miR-155 and its target angiotensin receptor type 1 (AT1R) are linked to the incidence of ischemic stroke (IS), but the underlying mechanisms remain to be clarified. 31721599 2020
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.100 GeneticVariation disease BEFREE Relationship between interleukin-10 polymorphisms and susceptibility to ischemic stroke: a Meta-analysis. 31722572 2020
Entrez Id: 338
Gene Symbol: APOB
APOB
0.100 AlteredExpression disease BEFREE Baseline LDL-C, non-high-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and apolipoprotein B levels were lower and lipoprotein(a) higher in patients with than without prior MI/ischemic stroke. 31076261 2020
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.100 Biomarker disease BEFREE The present study was conducted in order to investigate the effect of miR-31 on oxidative stress-induced neuronal injury in IS mice with the involvement of protein kinase D1 (PKD1) and the JAK/STAT3 pathway. 31517390 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation disease BEFREE The aim of this study was to investigate if interleukin 6 trans-signalling can identify individuals at risk for cardiovascular events (coronary artery disease and ischaemic stroke) among those at-low-intermediate risk. 31438723 2020
Entrez Id: 1401
Gene Symbol: CRP
CRP
0.100 Biomarker disease BEFREE The adjusted OR (95% CI) of IS per genetically predicted 10% higher CRP concentration, based on the three SNPs as the instruments, was 1.02 (0.94-1.11). 31692152 2020
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.100 GeneticVariation disease BEFREE Polymorphism of IL6 receptor gene is associated with ischaemic stroke in patients with metabolic syndrome. 31836512 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.100 Biomarker disease BEFREE 324 patients with acute ischemic stroke and TIA were further screened for PCSK9-inhibitor treatment eligibility. 31732461 2020
Entrez Id: 5340
Gene Symbol: PLG
PLG
0.100 Biomarker disease BEFREE Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke. 31552559 2020
Entrez Id: 5144
Gene Symbol: PDE4D
PDE4D
0.100 GeneticVariation disease BEFREE There was no association between clinical severity and recurrence with variants rs2383207 (CDKN2B-AS1) for atherothrombotic IS and variants rs879324 (ZFHX3), rs966221 (PDE4D), and rs152312 (PDE4D) for cardioembolic IS. 31757599 2020
Entrez Id: 100128998
Gene Symbol: C20orf181
C20orf181
0.100 Biomarker disease BEFREE Hesperidin reduces adverse symptomatic intracerebral hemorrhage by promoting TGF-β1 for treating ischemic stroke using tissue plasminogen activator. 31478148 2020
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 GeneticVariation disease BEFREE Influence of the Matrix Metalloproteinase 9 Geners3918242 Polymorphism on Development of Ischemic Stroke: A Meta-analysis. 31415895 2020
Entrez Id: 5130
Gene Symbol: PCYT1A
PCYT1A
0.100 Biomarker disease BEFREE Two blinded reviewers evaluated patients' eligibility for endovascular thrombectomy using published collateral imaging (multiphase CTA) criteria compared with CTP using the selection criteria of the Clinical Mismatch in the Triage of Wake Up and Late Presenting Strokes Undergoing Neurointervention with Trevo (DAWN) and Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke 3 (DEFUSE-3) trials. 31806593 2020
Entrez Id: 340348
Gene Symbol: TSPAN33
TSPAN33
0.100 Biomarker disease BEFREE The SPECT/CT-based assessment procedure of the volume of the penumbra may serve as an effective selecting tool when HBOT is administered for patients with ischemic stroke. 31846850 2020
Entrez Id: 255738
Gene Symbol: PCSK9
PCSK9
0.100 GeneticVariation disease BEFREE To assess potential differences between the efficacy and safety of the proprotein convertase subtilisin/kexin type 9 inhibitor, alirocumab, in patients with vs without prior myocardial infarction (MI)/ischemic stroke. 31076261 2020